How Do Your Genes Affect Your Risk of Melanoma, and What Can You Do About It?

Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity*

R Laskar, A Ferreiro-Iglesias, DT Bishop, MM Iles, PA Kanetsky, BK Armstrong, MH Law, AM Goldstein, JF Aitken, GG Giles, HA Robbins, AE Cust, GJ Mann, H Schmid, JL Hopper, BK Armstrong, E Holland, RF Kefford, MA Jenkins, JA Newton Bishop

2021-06-01

Background: Melanoma aetiology has been proposed to have two pathways, which are determined by naevi and type of sun exposure and ..

An independent external validation of melanoma risk prediction models using the Australian Melanoma Family Study

K Vuong, BK Armstrong, D Espinoza, JL Hopper, JF Aitken, GG Giles, H Schmid, GJ Mann, AE Cust, K McGeechan

2021-05-01

Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure

AE Cust, M Drummond, DT Bishop, L Azizi, H Schmid, MA Jenkins, JL Hopper, BK Armstrong, JF Aitken, RF Kefford, GG Giles, F Demenais, AM Goldstein, JH Barrett, PA Kanetsky, DE Elder, GJ Mann, JA Newton-Bishop

2019-10-01

Background: People at high risk of developing melanoma are usually identified by pigmentary and naevus phenotypes. Objective: We e..

Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies

AE Cust, M Drummond, PA Kanetsky, GJ Mann, H Schmid, JL Hopper, JF Aitken, BK Armstrong, GG Giles, E Holland, RF Kefford, MA Jenkins, JA Newton Bishop, P Affleck, JH Barrett, DT Bishop, J Harrison, MM Iles, J Randerson-Moor, M Harland

2018-12-01

It is unclear to what degree genomic and traditional (phenotypic and environmental) risk factors overlap in their prediction of me..

Sunscreen use and melanoma risk among young Australian adults

CG Watts, M Drummond, C Goumas, H Schmid, BK Armstrong, JF Aitken, MA Jenkins, GG Giles, JL Hopper, GJ Mann, AE Cust

2018-09-01

IMPORTANCE There are limited data among young adults on sunscreen use during childhood and adulthood and on the association of sun..

Accuracy of self-reported nevus and pigmentation phenotype compared with clinical assessment in a population-based study of young Australian Adults

AE Cust, KM Pickles, C Goumas, T Vu, H Schmid, E Nagore, J Kelly, JF Aitken, GG Giles, JL Hopper, MA Jenkins, GJ Mann

2015-04-01

Background: Awareness of individual risk may encourage improved prevention and early detection of melanoma. Methods: We evaluated ..

Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom

M Harland, AE Cust, C Badenas, YM Chang, EA Holland, P Aguilera, JF Aitken, BK Armstrong, JH Barrett, C Carrera, M Chan, J Gascoyne, GG Giles, C Agha-Hamilton, JL Hopper, MA Jenkins, PA Kanetsky, RF Kefford, I Kolm, J Lowery

2014-11-20

Background: Mutations in the CDKN2A and CDK4 genes predispose to melanoma. From three case-control studies of cutaneous melanoma, ..

Occupational sun exposure and risk of melanoma according to anatomical site

K Vuong, K McGeechan, BK Armstrong, AE Cust, GJ Mann, JF Aitken, GG Giles, RF Kefford, JL Hopper, H Schmid, EA Holland, MA Jenkins, M Berwick, CB Begg, I Orlow, A Kricker, A Venn, T Dwyer, RP Gallagher, LD Marrett

2014-06-01

Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inver..

MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: An Australian case-control-family study

AE Cust, C Goumas, K Vuong, JR Davies, JH Barrett, EA Holland, H Schmid, C Agha-Hamilton, BK Armstrong, RF Kefford, JF Aitken, GG Giles, DT Bishop, JA Newton-Bishop, JL Hopper, GJ Mann, MA Jenkins

2013-09-04

Background: Melanocortin-1 receptor (MC1R) gene variants are very common and are associated with melanoma risk, but their contribu..

MC1R genotypes and risk of melanoma before age 40 years: A population-based case-control-family study

AE Cust, C Goumas, EA Holland, C Agha-Hamilton, JF Aitken, BK Armstrong, GG Giles, RF Kefford, H Schmid, JL Hopper, GJ Mann, MA Jenkins

2012-08-01

The contribution of melanocortin-1 receptor (MC1R) gene variants to the development of early-onset melanoma is unknown. Using an A..

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

S Yokoyama, SL Woods, GM Boyle, LG Aoude, S MacGregor, V Zismann, M Gartside, AE Cust, R Haq, M Harland, JC Taylor, DL Duffy, K Holohan, K Dutton-Regester, JM Palmer, V Bonazzi, MS Stark, J Symmons, MH Law, C Schmidt

2011-12-01

So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. M..

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma

CI Amos, LE Wang, JE Lee, JE Gershenwald, WV Chen, S Fang, R Kosoy, M Zhang, AA Qureshi, S Vattathil, CW Schacherer, JM Gardner, Y Wang, D Tim bishop, JH Barrett, S Macgregor, NK Hayward, NG Martin, DL Duffy, GJ Mann

2011-12-01

We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 control..

Early-life sun exposure and risk of melanoma before age 40 years

AE Cust, MA Jenkins, C Goumas, BK Armstrong, H Schmid, JF Aitken, GG Giles, RF Kefford, JL Hopper, GJ Mann

2011-06-01

Objective: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages ..

Sunbed use during adolescence and early adulthood is associated with increased risk of early-onset melanoma

AE Cust, BK Armstrong, C Goumas, MA Jenkins, H Schmid, JL Hopper, RF Kefford, GG Giles, JF Aitken, GJ Mann

2011-05-01

Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ..

Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK

AE Cust, M Harland, E Makalic, D Schmidt, JG Dowty, JF Aitken, C Agha-Hamilton, BK Armstrong, JH Barrett, M Chan, YM Chang, J Gascoyne, GG Giles, EA Holland, RF Kefford, K Kukalizch, J Lowery, JA Randerson-Moor, H Schmid, CF Taylor

2011-04-01

Background CDKN2A mutations confer a substantial risk of cutaneous melanoma; however, the magnitude of risk is uncertain. Methods ..